Monitoring function in early age-related maculopathy: visual performance after 1 year

Feigl, Beatrix, Brown, Brian, Lovie-Kitchin, Janette E., & Swann, Peter G. (2005) Monitoring function in early age-related maculopathy: visual performance after 1 year. Eye, 19(11), pp. 1169-1177.

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Purpose. To monitor visual performance in early age-related maculopathy (ARM).

Methods. We measured monocular visual function - high-contrast visual acuity (HC-VA), central visual fields (mean sensitivity, MS), colour vision (desaturated Panel D-15), Pelli-Robson (P-R) and cone- and rod-mediated multifocal electroretinograms (mfERG) - in 13 ARM subjects and 13 age-matched control subjects with normal fundi at baseline and after one year. All had a visual acuity of 6/12 or better. The mfERG data were compared to templates derived from the control group at baseline. We analysed the mfERG results by averaging the central and peripheral fields and the superior and inferior fields (CP and SI methods) and by calculating the local responses.

Results. The mean rod-mediated responses were significantly delayed in the ARM group for the CP (p=0.04) and the SI methods (p=0.03) at baseline compared to the control group. This did not change significantly after one year, whereas the mean cone-mediated responses were within the normal range at both times. Although the local analysis revealed lower amplitudes for the cone- and rod-mediated responses at baseline this was not found after one year and only the local rod-mediated latencies were delayed at both times (p<0.01). HC-VA, desaturated Panel D-15 and P-R were significantly worse in the ARM group (p≤0.01) at baseline but did not show further significant deterioration. Progressive fundus changes were found in only two subjects (18%).

Conclusion. Although there was significant impairment of retinal function in early ARM at baseline no further deterioration was evident after one year.

Impact and interest:

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24 citations in Web of Science®
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ID Code: 6828
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
Keywords: age, related maculopathy, multifocal electroretinogram, multifocal ERG, psychophyics, monitoring, multifocal electroretinogram, early age, related maculopathy, cone, mediated function, rod, mediated function, mfERG, monitoring
DOI: 10.1038/sj.eye.6701711
ISSN: 0950-222X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 Nature Publishing Group
Deposited On: 05 Jul 2007 00:00
Last Modified: 29 Feb 2012 13:15

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