A bi-lineage conducive scaffold for osteochondral defect regeneration

Wu, Yan, Zhu, Shouan, Wu, Chengtie, Lu, Ping, Hu, Changchang, Xiong, Si, Chang, Jiang, Heng, Boon Chin, Xiao, Yin, & Ouyang, Hong Wei (2014) A bi-lineage conducive scaffold for osteochondral defect regeneration. Advanced Functional Materials, 24(28), pp. 4473-4483.

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Because cartilage and bone tissues have different lineage-specific biological properties, it is challenging to fabricate a single type of scaffold that can biologically fulfill the requirements for regeneration of these two lineages simultaneously within osteochondral defects. To overcome this challenge, a lithium-containing mesoporous bioglass (Li-MBG) scaffold is developed. The efficacy and mechanism of Li-MBG for regeneration of osteochondral defects are systematically investigated. Histological and micro-CT results show that Li-MBG scaffolds significantly enhance the regeneration of subchondral bone and hyaline cartilage-like tissues as compared to pure MBG scaffolds, upon implantation in rabbit osteochondral defects for 8 and 16 weeks. Further investigation demonstrates that the released Li+ ions from the Li-MBG scaffolds may play a key role in stimulating the regeneration of osteochondral defects. The corresponding mechanistic pathways involve Li+ ions enhancing the proliferation and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) through activation of the Wnt signalling pathway, as well as Li+ ions protecting chondrocytes and cartilage tissues from the inflammatory osteoarthritis (OA) environment through activation of autophagy. These findings suggest that the incorporation of Li+ ions into bioactive MBG scaffolds is a viable strategy for fabricating bi-lineage conducive scaffolds that enhance regeneration of osteochondral defects.

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8 citations in Scopus
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10 citations in Web of Science®

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ID Code: 68286
Item Type: Journal Article
Refereed: Yes
Keywords: bi-lineage scaffold, Li-MBG, osteochondral defect regeneration, dual functions
DOI: 10.1002/adfm.201304304
ISSN: 1616-301X
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 30 Jul 2014 00:24
Last Modified: 30 Jul 2014 20:53

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