Enterovirus71 (EV71) utilise host microRNAs to mediate host immune system enhancing survival during infection

Lui, Yan Long Edmund, Tan, Tuan Lin, Woo, Wee Hong, Timms, Peter, Hafner, Louise M., Tan, Kian Hwa, & Tan, Eng Lee (2014) Enterovirus71 (EV71) utilise host microRNAs to mediate host immune system enhancing survival during infection. PLOS One, 9(7), e102997-1.

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Abstract

Hand, Foot and Mouth Disease (HFMD) is a self-limiting viral disease that mainly affects infants and children. In contrast with other HFMD causing enteroviruses, Enterovirus71 (EV71) has commonly been associated with severe clinical manifestation leading to death. Currently, due to a lack in understanding of EV71 pathogenesis, there is no antiviral therapeutics for the treatment of HFMD patients. Therefore the need to better understand the mechanism of EV71 pathogenesis is warranted. We have previously reported a human colorectal adenocarcinoma cell line (HT29) based model to study the pathogenesis of EV71. Using this system, we showed that knockdown of DGCR8, an essential cofactor for microRNAs biogenesis resulted in a reduction of EV71 replication. We also demonstrated that there are miRNAs changes during EV71 pathogenesis and EV71 utilise host miRNAs to attenuate antiviral pathways during infection. Together, data from this study provide critical information on the role of miRNAs during EV71 infection.

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8 citations in Web of Science®

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50 since deposited on 13 Mar 2014
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ID Code: 68333
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Enterovirus 71 infectipons, Host microRNAs, Enhanced survival
DOI: 10.1371/journal.pone.0102997
ISSN: 1553-7366
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Virology (060506)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 The Author(s)
Copyright Statement: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and source are credited.
Deposited On: 13 Mar 2014 04:20
Last Modified: 06 May 2015 06:05

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