Crucial roles for olfactory ensheathing cells and olfactory mucosal cells in the repair of damaged neural tracts

Ekberg, Jenny A.K. & St John, James A. (2014) Crucial roles for olfactory ensheathing cells and olfactory mucosal cells in the repair of damaged neural tracts. Anatomical Records, 297(1), pp. 121-128.

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Olfactory ensheathing cells, the glial cells of the olfactory nervous system, exhibit unique growth-promoting and migratory properties that make them interesting candidates for cell therapies targeting neuronal injuries such as spinal cord injury. Transplantation of olfactory cells is feasible and safe in humans; however, functional outcomes are highly variable with some studies showing dramatic improvements and some no improvements at all. We propose that the reason for this is that the identity and purity of the cells is different in each individual study. We have shown that olfactory ensheathing cells are not a uniform cell population and that individual subpopulations of OECs are present in different regions of the olfactory nervous system, with strikingly different behaviors. Furthermore, the presence of fibroblasts and other cell types in the transplant can dramatically alter the behavior of the transplanted glial cells. Thus, a thorough characterization of the differences between olfactory ensheathing cell subpopulations and how the behavior of these cells is affected by the presence of other cell types is highly warranted.

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6 citations in Scopus
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7 citations in Web of Science®

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ID Code: 68344
Item Type: Journal Article
Refereed: Yes
Additional Information: Special Issue: A New Age of Regenerative Medicine: Fusion of Tissue Engineering and Stem Cell Research
Additional URLs:
Keywords: olfactory nervous system, glial cells, nerve repair, cell migration
DOI: 10.1002/ar.22803
ISSN: 1932-8494
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 12 Mar 2014 23:53
Last Modified: 15 Sep 2016 00:55

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