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The ocular response to extended wear of a high Dk silicone hydrogel contact lens

Fonn, Desmond, MacDonald, Karen E., Richter, Doris, & Pritchard, Nicola (2002) The ocular response to extended wear of a high Dk silicone hydrogel contact lens. Clinical and Experimental Optometry, 85(3), pp. 176-182.

Abstract

Purpose: A four-month extended wear clinical trial was conducted to compare the ocular effects of a high Dk Balafilcon A silicone hydrogel lens and a low Dk HEMA 38.6 per cent H20 soft lens. Method: Twenty-four subjects who were adapted to daily wear of soft lenses wore a high Dk lens in one eye and a low Dk HEMA lens in the other eye for four months on an extended wear basis after one week of daily wear. Thirteen progress evaluations were conducted using standard clinical procedures. Results: Eighteen subjects (75 per cent) completed the study. The high Dk lens induced significantly less bulbar and limbal injection and corneal vascularisation than the low Dk HEMA lens (p < 0.05). Epithelial microcysts were observed only in the eyes wearing the low Dk lens. A significant increase in myopia was found in the eyes wearing the low Dk HEMA lens (mean = 0.50 D, p < 0.01) compared to the insignificant myopic increase of 0.06 D in the eyes wearing the high Dk lens. Three subjects developed small infiltrates in the high Dk lens wearing eyes and significantly more post-lens debris was observed under the high Dk lens. Six subjects developed papillary conjunctivitis in the eye wearing silicone hydrogel lenses but only two of those were discontinued from the study. Conclusion: No hypoxia-related effects were observed with extended wear of the high Dk Balafilcon A silicone hydrogel lens.

Impact and interest:

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ID Code: 6847
Item Type: Journal Article
Additional URLs:
Keywords: corneal swelling, epithelial microcysts, limbal injection, myopic shift, silicone hydrogel soft lens, vascularisation
ISSN: 0816-4622
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2002 Australian Optometrical Association
Copyright Statement: The contents of this journal from 1998 to 2005 can be freely accessed online via the journal’s web page (see link).
Deposited On: 03 Apr 2007
Last Modified: 11 Aug 2011 00:08

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