Nanohybrids of silver particles on clay platelets delaminate Pseudomonas biofilms

Tseng, Li-Ping, Juan, Chih-Yin, Lin, Shiun-Long, Doran, Michael, Lin, Jiang-Jen, Hsu, Shan-hui, Liao, Jiunn-Wang, Shen, Ching-I, & Su, Hong-Lin (2014) Nanohybrids of silver particles on clay platelets delaminate Pseudomonas biofilms. Nanomedicine, 9(7), pp. 1019-1033.

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Abstract

Aim To evaluate the effectiveness of novel nanohybrids, composed of silver nanoparticles and nanoscale silicate platelets, to clear Pseudomonas aeruginosa biofilms. Materials & methods The nanohybrids were manufactured from an in situ reduction of silver salts in the silicate platelet dispersion, and then applied to biofilms in vitro and in vivo. Results In reference to the biocidal effects of gentamycin, the nanohybrids mitigated the spreading of the biofilms, and initiated robust cell death and exfoliation from the superficial layers of the biofilms in vitro. In vivo, the nanohybrids exhibited significant therapeutic effects by eliminating established biofilms from infected corneas and promoting the recovery of corneal integrity. Conclusion All of the evaluations indicate the high potency of the newly developed silver nanoparticle/nanoscale silicate platelet nanohybrids for eliminating biofilms.

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ID Code: 68708
Item Type: Journal Article
Refereed: Yes
Keywords: Antimicrobial, Silver, nanoparticle, cornea
DOI: 10.2217/nnm.13.53
ISSN: 1743-5889
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomedical Engineering not elsewhere classified (090399)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Future Medicine Ltd
Deposited On: 18 Mar 2014 23:12
Last Modified: 17 Dec 2014 06:19

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