Mesenchymal stem cell therapies for bone and tendon conditions

Young, Mark & Doran, Michael (2013) Mesenchymal stem cell therapies for bone and tendon conditions. In Chase, L.G. & Vemuri, M.C. (Eds.) Mesenchymal Stem Cell Therapy. Springer, New York, pp. 117-144.

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Abstract

Bone, tendon, and cartilage are highly specialized musculoskeletal connective tissues that are subject to injury and degeneration. These tissues have relatively poor healing capabilities, and coupled with their variable response to established medical treatments, produce significant morbidity. Mesenchymal stem cells (MSCs) are capable of regenerating skeletal tissues and therefore offer great promise in the treatment of connective tissue pathologies. Adult MSCs are multipotent cells that possess the properties of proliferation and differentiation into all connective tissues. Furthermore, they can be gene modified to secrete growth factors and utilized in connective tissue engineering. Potential MSC-based therapies for bone and tendon conditions are reviewed in this chapter.

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ID Code: 68710
Item Type: Book Chapter
DOI: 10.1007/978-1-62703-200-1_7
ISBN: 9781627031998
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomedical Engineering not elsewhere classified (090399)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Springer
Deposited On: 18 Mar 2014 23:19
Last Modified: 20 Mar 2014 01:44

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