Advances in mass spectrometry for lipidomics

Blanksby, S.J. & Mitchell, T.W. (2010) Advances in mass spectrometry for lipidomics. In Yeung, E.S. & Zare, R.N. (Eds.) Annual Review of Analytical Chemistry. Annual Reviews Inc, Palo Alto, pp. 433-465.

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Recent expansion in research in the field of lipidomics has been driven by the development of new mass spectrometric tools and protocols for the identification and quantification of molecular lipids in complex matrices. Although there are similarities between the field of lipidomics and the allied field of mass spectrometry (e.g., proteomics), lipids present some unique advantages and challenges for mass spectrometric analysis. The application of electrospray ionization to crude lipid extracts without prior fractionation-the so-called shotgun approach-is one such example, as it has perhaps been more successfully applied in lipidomics than in any other discipline. Conversely, the diverse molecular structure of lipids means that collision-induced dissociation alone may be limited in providing unique descriptions of complex lipid structures, and the development of additional, complementary tools for ion activation and analysis is required to overcome these challenges. In this article, we discuss the state of the art in lipid mass spectrometry and highlight several areas in which current approaches are deficient and further innovation is required.

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93 citations in Web of Science®

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ID Code: 68809
Item Type: Book Chapter
DOI: 10.1146/annurev.anchem.111808.073705
ISBN: 9780824344030
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 19 Mar 2014 04:55
Last Modified: 25 Oct 2015 16:19

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