Surface analysis of lipids by mass spectrometry : More than just imaging

Ellis, S. R., Brown, S. H., In Het Panhuis, M., Blanksby, S. J., & Mitchell, T. W. (2013) Surface analysis of lipids by mass spectrometry : More than just imaging. Progress in Lipid Research, 52(4), pp. 329-353.

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Abstract

Mass spectrometry is now an indispensable tool for lipid analysis and is arguably the driving force in the renaissance of lipid research. In its various forms, mass spectrometry is uniquely capable of resolving the extensive compositional and structural diversity of lipids in biological systems. Furthermore, it provides the ability to accurately quantify molecular-level changes in lipid populations associated with changes in metabolism and environment; bringing lipid science to the "omics" age. The recent explosion of mass spectrometry-based surface analysis techniques is fuelling further expansion of the lipidomics field. This is evidenced by the numerous papers published on the subject of mass spectrometric imaging of lipids in recent years. While imaging mass spectrometry provides new and exciting possibilities, it is but one of the many opportunities direct surface analysis offers the lipid researcher. In this review we describe the current state-of-the-art in the direct surface analysis of lipids with a focus on tissue sections, intact cells and thin-layer chromatography substrates. The suitability of these different approaches towards analysis of the major lipid classes along with their current and potential applications in the field of lipid analysis are evaluated. © 2013 Elsevier Ltd. All rights reserved.

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ID Code: 68874
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Ambient ionization, Lipidomics, Mass spectrometry imaging, Thin-layer chromatography, ARC
DOI: 10.1016/j.plipres.2013.04.005
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000)
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Elsevier
Deposited On: 20 Mar 2014 00:28
Last Modified: 14 May 2015 03:52

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