Mesenchymal stem cells, neural lineage potential, heparan sulfate proteoglycans and the matrix

Okolicsanyi, Rachel K., Griffiths, Lyn R., & Haupt, Larisa M. (2014) Mesenchymal stem cells, neural lineage potential, heparan sulfate proteoglycans and the matrix. Developmental Biology, 388(1), pp. 1-10.

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Along with the tri-lineage of bone, cartilage and fat, human mesenchymal stem cells (hMSCs) retain neural lineage potential. Multiple factors have been described that influence lineage fate of hMSCs including the extracellular microenvironment or niche. The niche includes the extracellular matrix (ECM) providing structural composition, as well as other associated proteins and growth factors, which collectively influence hMSC stemness and lineage specification. As such, lineage specific differentiation of MSCs is mediated through interactions including cell–cell and cell–matrix, as well as through specific signalling pathways triggering downstream events. Proteoglycans (PGs) are ubiquitous within this microenvironment and can be localised to the cell surface or embedded within the ECM. In addition, the heparan sulfate (HS) and chondroitin sulfate (CS) families of PGs interact directly with a number of growth factors, signalling pathways and ECM components including FGFs, Wnts and fibronectin. With evidence supporting a role for HSPGs and CSPGs in the specification of hMSCs down the osteogenic, chondrogenic and adipogenic lineages, along with the localisation of PGs in development and regeneration, it is conceivable that these important proteins may also play a role in the differentiation of hMSCs toward the neuronal lineage. Here we summarise the current literature and highlight the potential for HSPG directed neural lineage fate specification in hMSCs, which may provide a new model for brain damage repair.

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9 citations in Scopus
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10 citations in Web of Science®

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ID Code: 69142
Item Type: Journal Article
Refereed: Yes
Keywords: Proteoglycans, Heparan Sulfate, Human mesenchymal stem cells, Neuronalniche
DOI: 10.1016/j.ydbio.2014.01.024
ISSN: 0012-1606
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Developmental Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Developmental Biology, [VOL 388, ISSUE 1, (2014)] DOI: 10.1016/j.ydbio.2014.01.024
Deposited On: 25 Mar 2014 22:59
Last Modified: 18 Jun 2015 02:50

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