Genetic analysis of GRIA2 and GRIA4 genes in migraine

Gasparini, Claudia F., Sutherland, Heidi, Haupt, Larisa M., & Griffiths, Lyn R. (2013) Genetic analysis of GRIA2 and GRIA4 genes in migraine. Headache : The Journal of Head and Face Pain, 54(2), pp. 303-312.

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Migraine is a brain disorder affecting ∼12% of the Caucasian population. Genes involved in neurological, vascular, and hormonal pathways have all been implicated in predisposing individuals to developing migraine. The migraineur presents with disabling head pain and varying symptoms of nausea, emesis, photophobia, phonophobia, and occasionally visual sensory disturbances. Biochemical and genetic studies have demonstrated dysfunction of neurotransmitters: serotonin, dopamine, and glutamate in migraine susceptibility. Glutamate mediates the transmission of excitatory signals in the mammalian central nervous system that affect normal brain function including cognition, memory and learning. The aim of this study was to investigate polymorphisms in the GRIA2 and GRIA4 genes, which encode subunits of the ionotropic AMPA receptor for association in an Australian Caucasian population.


Genotypes for each polymorphism were determined using high resolution melt analysis and the RFLP method.


Statistical analysis showed no association between migraine and the GRIA2 and GRIA4 polymorphisms investigated.


Although the results of this study showed no significant association between the tested GRIA gene variants and migraine in our Australian Caucasian population further investigation of other components of the glutamatergic system may help to elucidate if there is a relationship between glutamatergic dysfunction and migraine.

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ID Code: 69147
Item Type: Journal Article
Refereed: Yes
Keywords: migraine with aura, migraine without aura, migraine, AMPA receptor, glutamate, GRIA2, GRIA4
DOI: 10.1111/head.12234
ISSN: 0017-8748
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 American Headache Society
Deposited On: 25 Mar 2014 23:09
Last Modified: 04 Aug 2014 11:35

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