Novel sequential methods in dose-finding designs : extensions of the continual reassessment method

Darssan, Darsy (2014) Novel sequential methods in dose-finding designs : extensions of the continual reassessment method. PhD thesis, Queensland University of Technology.


Dose-finding trials are a form of clinical data collection process in which the primary objective is to estimate an optimum dose of an investigational new drug when given to a patient. This thesis develops and explores three novel dose-finding design methodologies. All design methodologies presented in this thesis are pragmatic. They use statistical models, incorporate clinicians' prior knowledge efficiently, and prematurely stop a trial for safety or futility reasons. Designing actual dose-finding trials using these methodologies will minimize practical difficulties, improve efficiency of dose estimation, be flexible to stop early and reduce possible patient discomfort or harm.

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ID Code: 69374
Item Type: QUT Thesis (PhD)
Supervisor: Pettitt, Tony & Thompson, Helen
Keywords: Continual Reassessment Method, Global cross-ratio, Adverse event relatedness, EM Algorithm, Prior data
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 15 May 2014 05:17
Last Modified: 10 Sep 2015 02:24

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