TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue--influence of BMI and adipose distribution

Good, M., Newell, F. M., Haupt, Larisa M., Whitehead, J. P., Hutley, L. J., & Prins, J. B. (2006) TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue--influence of BMI and adipose distribution. Diabetes and Vascular Disease Research, 3(1), pp. 26-33.

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Tumour necrosis factor (TNF)alpha is implicated in the relationship between obesity and insulin resistance/ type 2 diabetes. In an effort to understand this association better we (i) profiled gene expression patterns of TNF, TNFR1 and TNFR2 and (ii) investigated the effects of TNF on glucose uptake in isolated adipocytes and adipose tissue explants from omental and subcutaneous depots from lean, overweight and obese individuals. TNF expression correlated with expression of TNFR2, but not TNFR1, and TNF and TNFR2 expression increased in obesity. TNFR1 expression was higher in omental than in subcutaneous adipocytes. Expression levels of TNF or either receptor did not differ between adipocytes from individuals with central and peripheral obesity. TNF only suppressed glucose uptake in insulin-stimulated subcutaneous tissue and this suppression was only observed in tissue from lean subjects. These data support a relationship between the TNF system and body mass index (BMI), but not fat distribution, and suggest depot specificity of the TNF effect on glucose uptake. Furthermore, adipose tissue from obese subjects already appears insulin 'resistant' and this may be a result of the increased TNF levels.

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ID Code: 69467
Item Type: Journal Article
Refereed: Yes
Additional Information: Good, Manuela Newell, Felicity M Haupt, Larisa M Whitehead, Jonathan P Hutley, Louise J Prins, Johannes B eng Wellcome Trust/United Kingdom Research Support, Non-U.S. Gov't England 2006/06/21 09:00 Diab Vasc Dis Res. 2006 May;3(1):26-33.
Additional URLs:
Keywords: Abdominal Fat/*metabolism, Adipocytes/*metabolism, Adult, Aged, Body Fat Distribution, Body Mass Index, Deoxyglucose/metabolism, Female, Humans, Insulin, Insulin Resistance/*physiology, Male, Middle Aged, Receptors, Tumor Necrosis Factor/*metabolism, Tumor Necrosis Factor-alpha/*metabolism, Waist-Hip Ratio
DOI: 10.3132/dvdr.2006.003
ISSN: 1752-8984 (online) 1479-1641 (Print)
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Development Proliferation and Death (060103)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Sage Publications Ltd.
Copyright Statement: Author's Pre-print: author can archive pre-print (ie pre-refereeing) Author's Post-print: author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: author cannot archive publisher's version/PDF
Deposited On: 06 Apr 2014 23:08
Last Modified: 06 Apr 2014 23:08

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