Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence

Tlsty, Thea D., Romanov, Serguei R., Kozakiewicz, B. Krystyna, Holst, Charles R., Haupt, Larisa M., & Crawford, Yongping G. (2001) Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence. Journal of Mammary Gland Biology and Neoplasia, 6(2), pp. 235-243.

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The genomic changes that foster cancer can be either genetic or epigenetic in nature. Early studies focused on genetic changes and how mutational events contribute to changes in gene expression. These point mutations, deletions and amplifications are known to activate oncogenes and inactivate tumor suppressor genes. More recently, multiple epigenetic changes that can have a profound effect on carcinogenesis have been identified. These epigenetic events, such as the methylation of promoter sequences in genes, are under active investigation. In this review we will describe a methylation event that occurs during the propagation of human mammary epithelial cells (HMEC) in culture and detail the accompanying genetic alterations that have been observed.

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ID Code: 69498
Item Type: Journal Article
Refereed: Yes
Additional Information: Tlsty, T D
Romanov, S R
Kozakiewicz, B K
Holst, C R
Haupt, L M
Crawford, Y G
Comparative Study
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
2001/08/15 10:00
J Mammary Gland Biol Neoplasia. 2001 Apr;6(2):235-43.
Additional URLs:
Keywords: Breast/*metabolism, Cell Aging/*physiology, Cell Division, Cell Line, Cell Transformation, Neoplastic, Cells, Cultured, *Chromosome Aberrations, DNA Methylation, Epithelial Cells/*metabolism, Female, Fibroblasts/metabolism, Humans, Oncogene Proteins, Viral/metabolism, Promoter Regions, Genetic
DOI: 10.1023/A:1011369026168
ISSN: 1083-3021
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Development Proliferation and Death (060103)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Apr 2014 01:19
Last Modified: 07 Apr 2014 01:59

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