Poly(2-oxazoline) hydrogels as next generation three dimensional cell supports

Dargaville, Tim R., Hollier, Brett G., Shokoohmand, Ali, & Hoogenboom, Richard (2014) Poly(2-oxazoline) hydrogels as next generation three dimensional cell supports. Cell Adhesion and Migration, 8(2).

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Abstract

Synthetic hydrogels selectively decorated with cell adhesion motifs are rapidly emerging as promising substrates for 3D cell culture. When cells are grown in 3D they experience potentially more physiologically relevant cell-cell interactions and physical cues compared with traditional 2D cell culture on stiff surfaces. A newly developed polymer based on poly(2-oxazoline)s has been used for the first time to control attachment of fibroblast cells and is discussed here for its potential use in 3D cell culture with particular focus on cancer cells towards the ultimate aim of high throughput screening of anti-cancer therapies. Advantages and limitations of using poly(2-oxazoline) hydrogels are discussed and compared with more established polymers, especially polyethylene glycol (PEG).

Impact and interest:

4 citations in Scopus
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4 citations in Web of Science®

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ID Code: 69509
Item Type: Journal Article
Refereed: Yes
Keywords: polyoxazoline, poly(2-oxazoline), hydrogel, 3D, 3D cell culture
ISSN: 1933-6926
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MACROMOLECULAR AND MATERIALS CHEMISTRY (030300)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Copyright 2014 Landes Bioscience
Deposited On: 28 Mar 2014 00:52
Last Modified: 16 Sep 2016 16:27

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