Why are there Different Age Related Trends for Different Chemicals?
Mueller, Jochen F. & Toms, Leisa-Maree L. (2010) Why are there Different Age Related Trends for Different Chemicals? In Isobe, Tomohiko, Nomiyama, Kei, Subramanian, Annamalai, & Tanabe, Shinsuke (Eds.) Environmental Specimen Bank : Exploring Possibility of Setting-up ESBs in Developing Countries. Terrapub, pp. 119-124.
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Persistent organic pollutants (POPs) such as dioxins, PCBs, persistent organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs) as well as perfluorinated compounds (PFCs) and triclosan are ubiquitous in the human population. In Australia, we have pooled and subsequently analysed over 10 000 human serum samples for the determination of these chemicals by age group (0–0.5; 0.6–1; 1.1–1.5; 1.6–2; 2.1–2.5; 2.6–3; 3.1–3.5; 3.6–4; 4.1–6; 6.1–9; 9.1–12; 12.1–15; 16–30; 31–45; 46–60 and >60 years) and gender. The results of this analysis were then used to assess the trends of these different chemicals as a function of age, gender and to a lesser extent region. Our data demonstrate clear chemical specific age trends. In particular we demonstrate that for the traditional POPs there is an increase in body burden with age whereas the opposite is true for chemicals such as PBDEs. For PFCs we find chemical specific age trends that vary from compound to compound. For triclosan we show that no apparent age trend is observable. The results of the study and its implications to the collection and archiving of samples for retrospective analysis are discussed.
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|Item Type:||Book Chapter|
|Keywords:||age trends, dioxins, polybrominated diphenyl ethers, perfluorinated compounds, Australia|
|Subjects:||Australian and New Zealand Standard Research Classification > ENVIRONMENTAL SCIENCES (050000) > OTHER ENVIRONMENTAL SCIENCES (059900) > Environmental Sciences not elsewhere classified (059999)|
|Copyright Owner:||Copyright 2010 TERRAPUB, Tokyo|
|Deposited On:||03 Apr 2014 01:23|
|Last Modified:||12 Dec 2014 03:40|
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