Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

Seim, Inge, Fang, Xiaodong, Xiong, Zhiqiang, Lobanov, Alexey V., Huang, Zhiyong, Ma, Siming, Feng, Yue, Turanov, Anton A., Zhu, Yabing, Lenz, Tobias L., Gerashchenko, Maxim V., Fan, Dingding, Hee Yim, Sun, Yao, Xiaoming, Jordan, Daniel, Xiong, Yingqi, Ma, Yong, Lyapunov, Andrey N., Chen, Guanxing, Kulakova, Oksana I., Sun, Yudong, Lee, Sang-Goo, Bronson, Roderick T., Moskalev, Alexey A., Sunyaev, Shamil R., Zhang, Guojie, Krogh, Anders, Wang, Jun, & Gladyshev, Vadim N. (2013) Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii. Nature Communications, 4(2212), pp. 1-8.

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Abstract

Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt’s bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4–8 g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt’s bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt’s bat.

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ID Code: 69778
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: genome, transcriptome, longevity, ageing, bats, comparative genomics, endocrinology
DOI: 10.1038/ncomms3212
ISSN: 2041-1723 (online) 1083-8155 (print)
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Genomics (060408)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Molecular Evolution (060409)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Macmillan Publishers Limited. All rights reserved.
Copyright Statement: Author's Pre-print: author can archive pre-print (ie pre-refereeing)
Author's Post-print: subject to Restrictions below, author can archive post-print (ie final draft post-refereeing)
Restrictions:
6 months embargo
Publisher's Version/PDF: author cannot archive publisher's version/PDF
Deposited On: 03 Apr 2014 01:43
Last Modified: 03 Apr 2014 23:24

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