Direct lipid profiling of single cells from inkjet printed microarrays

Ellis, S.R., Ferris, C.J., Gilmore, K.J., Mitchell, T.W., Blanksby, S.J., & In Het Panhuis, M. (2012) Direct lipid profiling of single cells from inkjet printed microarrays. Analytical chemistry, 84(22), pp. 9679-9683.

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The on-demand printing of living cells using inkjet technologies has recently been demonstrated and allows for the controlled deposition of cells in microarrays. Here, we show that such arrays can be interrogated directly by robot-controlled liquid microextraction coupled with chip-based nanoelectospray mass spectrometry. Such automated analyses generate a profile of abundant membrane lipids that are characteristic of cell type. Significantly, the spatial control in both deposition and extraction steps combined with the sensitivity of the mass spectrometric detection allows for robust molecular profiling of individual cells. © 2012 American Chemical Society.

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23 citations in Web of Science®

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ID Code: 69965
Item Type: Journal Article
Refereed: Yes
DOI: 10.1021/ac302634u
ISSN: 0003-2700
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 08 Apr 2014 05:39
Last Modified: 15 Apr 2014 03:51

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