Chlamydia pneumoniae infection of Dentritic cells and its role in asthma exacerbations

Hossain, Mohammed Imran (2014) Chlamydia pneumoniae infection of Dentritic cells and its role in asthma exacerbations. Masters by Research thesis, Queensland University of Technology.

Abstract

Chlamydia infections are associated with exacerbations of asthma however the mechanisms are poorly understood. In this thesis we infected dendritic cells from healthy controls and asthmatic patients to determine if the immune response to chlamydial infection by these key immune cells could explain this association of chlamydial infection with asthma attacks. Infected dendritic cells from asthmatic patients showed increased expression of multiple inflammatory cytokine genes and genes for several tissue remodelling proteins, suggesting that infected dendritic cells play a central role in driving the airways damage associated with asthma. The findings provide a greater understanding of the role of infections in asthma and may provide a basis for new therapies to treat this important disease.

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49 since deposited on 09 May 2014
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ID Code: 70453
Item Type: QUT Thesis (Masters by Research)
Supervisor: Beagley, Kenneth & Timms, Peter
Keywords: Chlamydia pneumoniae, MoDC, asthma, airway remodelling, DC, cytokine
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 09 May 2014 01:54
Last Modified: 12 Nov 2015 04:55

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