Analysis of strain-rate dependent mechanical behavior of single chondrocyte : a finite element study

Nguyen, Trung Dung, Gu, YuanTong, Oloyede, Adekunle, & Senadeera, Wijitha (2014) Analysis of strain-rate dependent mechanical behavior of single chondrocyte : a finite element study. International Journal of Computational Methods, 11(Supp1), p. 1344005.


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Various studies have been conducted to investigate the effects of impact loading on cartilage damage and chondrocyte death. These have shown that the rate and magnitude of the applied strain significantly influence chondrocyte death, and that cell death occurred mostly in the superficial zone of cartilage suggesting the need to further understand the fundamental mechanisms underlying the chondrocytes death induced at certain levels of strain-rate. To date there is no comprehensive study providing insight on this phenomenon. The aim of this study is to examine the strain-rate dependent behavior of a single chondrocyte using a computational approach based on Finite Element Method (FEM). An FEM model was developed using various mechanical models, which were Standard Neo-Hookean Solid (SnHS), porohyperelastic (PHE) and poroviscohyperelastic (PVHE) to simulate Atomic Force Microscopy (AFM) experiments of chondrocyte. The PVHE showed, it can capture both relaxation and loading rate dependent behaviors of chondrocytes, accurately compared to other models.

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2 citations in Scopus
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ID Code: 70522
Item Type: Journal Article
Refereed: Yes
Keywords: Porohyperelastic; chondrocyte; finite element method (FEM); biomechanics
DOI: 10.1142/S0219876213440052
ISSN: 1793-6969
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 World Scientific Publishing Company
Copyright Statement: Electronic version of an article published as [International Journal of Computational Methods, Volume 11, No. Suppl. 1, 2014, 1344005] [10.1142/S0219876213440052] © [copyright World Scientific Publishing Company] []
Deposited On: 28 Apr 2014 00:15
Last Modified: 14 May 2015 05:45

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