Bone regeneration based on tissue engineering conceptions – a 21st century perspective

Henkel, Jan, Woodruff, Maria A., Epari, Devakara R., Steck, Roland, Glatt, Vaida, Dickinson, Ian C., Choong, Peter F.M., Schuetz, Michael A., & Hutmacher, Dietmar W. (2013) Bone regeneration based on tissue engineering conceptions – a 21st century perspective. Bone Research, 1(3), pp. 216-248.

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The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteo- conductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineer- ing and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental “origin” require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.

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ID Code: 70526
Item Type: Journal Article
Refereed: Yes
Keywords: bone tissue engineering, regenerative medicine, additve manufacturing, clinical translation, scaffolds
DOI: 10.4248/BR201303002
ISSN: 20954700
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 27 Apr 2014 23:48
Last Modified: 28 Apr 2014 21:28

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