Superoxide does react with peroxides : direct observation of the haber-weiss reaction in the gas phase

Blanksby, S.J., Bierbaum, V.M., Ellison, G.B., & Kato, S. (2007) Superoxide does react with peroxides : direct observation of the haber-weiss reaction in the gas phase. Angewandte Chemie-International Edition, 119(26), pp. 5036-5038.

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The fact that nature provides specific enzymes to selectively remove superoxide (O2.−) from aerobic organisms, namely, the superoxide dismutase enzymes,1 has led to the suggestion that this radical ion may cause the oxidative damage associated with degradative disease and aging.2 Intriguingly, however, superoxide itself is relatively unreactive toward most cellular components, which suggests that dismutase enzymes may ultimately protect the cell against more pernicious oxidants formed from superoxide. As such, there is increasing interest in the endogenous chemistry of superoxide and the pathways by which it might beget more reactive oxygen species. Protonation of superoxide to form the hydroperoxyl radical (HOO.) and dismutation of the same species to hydrogen peroxide (HOOH), with subsequent metal-catalyzed reduction to the hydroxyl radical (HO.), are well-characterized processes in which both the HOO. and HO. radicals are significantly more reactive than their common progenitor.2 Recent examples, however, have also linked superoxide to the putative production of singlet oxygen3 and ozone,4, 5 although the definitive characterization of these chemistries in the cellular milieu has proved challenging

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ID Code: 70654
Item Type: Journal Article
Refereed: Yes
Additional Information: Blanksby, Stephen J. Bierbaum, Veronica M. Ellison, G. Barney Kato, Shuji
Wiley-v c h verlag gmbh
Keywords: haber-Weiss reaction, peroxides, radical ions, reaction mechanisms, reactive species, active thermochemical tables, neutrophils produce ozone, hydrogen-peroxide, rate constants, ion, oxygen, o2, hydroperoxides, hydration, acidity
DOI: 10.1002/anie.200700219
ISSN: 1433-7851
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 29 Apr 2014 03:30
Last Modified: 15 Jun 2014 17:50

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