Numerical estimation of 3D mechanical forces exerted by cells on non-linear materials
Palacio, J., Jorge-Peñas, A., Muñoz-Barrutia, A., Ortiz-de-Solorzano, C., de Juan Pardo, E.M., & García-Aznar, J.M. (2013) Numerical estimation of 3D mechanical forces exerted by cells on non-linear materials. Journal of Biomechanics, 46(1), pp. 50-55.
The exchange of physical forces in both cell-cell and cell-matrix interactions play a significant role in a variety of physiological and pathological processes, such as cell migration, cancer metastasis, inflammation and wound healing. Therefore, great interest exists in accurately quantifying the forces that cells exert on their substrate during migration. Traction Force Microscopy (TFM) is the most widely used method for measuring cell traction forces. Several mathematical techniques have been developed to estimate forces from TFM experiments. However, certain simplifications are commonly assumed, such as linear elasticity of the materials and/or free geometries, which in some cases may lead to inaccurate results. Here, cellular forces are numerically estimated by solving a minimization problem that combines multiple non-linear FEM solutions. Our simulations, free from constraints on the geometrical and the mechanical conditions, show that forces are predicted with higher accuracy than when using the standard approaches.
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|Item Type:||Journal Article|
|Keywords:||Traction Force Microscopy, Non-linear mechanics, Finite element modeling, Inverse analysis, Mechano-sensing|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2012 Elsevier Ltd|
|Copyright Statement:||This is the author’s version of a work that was accepted for publication in Journal of Biomechanics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Biomechanics, [VOL 46, ISSUE 1, (2013)] DOI: Journal of Biomechanics|
|Deposited On:||30 Apr 2014 22:33|
|Last Modified:||02 May 2014 00:31|
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