Computer simulation of scaffold degradation

Erkizia, G., Rainer, A., de Juan Pardo, E.M., & Aldazabal, J. (2010) Computer simulation of scaffold degradation. Journal of Physics : Conference Series, 252(1), 012004.

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Abstract

Scaffolds are porous biocompatible materials with suitable microarchitectures that are designed to allow for cell adhesion, growth and proliferation. They are used in combination with cells in regenerative medicine to promote tissue regeneration by means of a controlled deposition of natural extracellular matrix by the hosted cells therein. This healing process is in many cases accompanied by scaffold degradation up to its total disappearance when the scaffold is made of a biodegradable material.

This work presents a computational model that simulates the degradation of scaffolds. The model works with three-dimensional microstructures, which have been previously discretised into small cubic homogeneous elements, called voxels. The model simulates the evolution of the degradation of the scaffold using a Monte Carlo algorithm, which takes into account the curvature of the surface of the fibres.

The simulation results obtained in this study are in good agreement with empirical degradation measurements performed by mass loss on scaffolds after exposure to an etching alkaline solution.

Impact and interest:

1 citations in Scopus
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ID Code: 70772
Item Type: Journal Article
Refereed: Yes
DOI: 10.1088/1742-6596/252/1/012004
ISSN: 1742-6596
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2010 Published under licence by IOP Publishing Ltd
Deposited On: 30 Apr 2014 23:02
Last Modified: 16 Jul 2014 00:44

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