Optimization approaches for the design of additively manufactured scaffolds

Giannitelli, Sara M., Rainer, Alberto, Accoto, Dino, Porcellinis, Stefano, de Juan-Pardo, Elena M., Guglielmelli, Eugenio, & Trombetta, Marcella (2014) Optimization approaches for the design of additively manufactured scaffolds. In Fernandes, P.R & Bartolo, P.J. (Eds.) Tissue Engineering. Springer, Netherlands, pp. 113-128.

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Scaffolds play a pivotal role in tissue engineering, promoting the synthesis of neo extra-cellular matrix (ECM), and providing temporary mechanical support for the cells during tissue regeneration. Advances introduced by additive manufacturing techniques have significantly improved the ability to regulate scaffold architecture, enhancing the control over scaffold shape and porosity. Thus, considerable research efforts have been devoted to the fabrication of 3D porous scaffolds with optimized micro-architectural features. This chapter gives an overview of the methods for the design of additively manufactured scaffolds and their applicability in tissue engineering (TE). Along with a survey of the state of the art, the Authors will also present a recently developed method, called Load-Adaptive Scaffold Architecturing (LASA), which returns scaffold architectures optimized for given applied mechanical loads systems, once the specific stress distribution is evaluated through Finite Element Analysis (FEA).

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ID Code: 70801
Item Type: Book Chapter
DOI: 10.1007/978-94-007-7073-7_6
ISBN: 9789400770737
ISSN: 1871-3033
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 Springer
Deposited On: 30 Apr 2014 23:18
Last Modified: 04 May 2014 21:22

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