Proteases : common culprits in human skin disorders

De Veer, Simon J., Furio, Laetitia, Harris, Jonathan M., & Hovnanian, Alain (2014) Proteases : common culprits in human skin disorders. Trends in Molecular Medicine, 20(3), pp. 166-178.

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Recent findings from the clinic and the laboratory have transformed the way proteases and their inhibitors are perceived in the outermost layer of the skin, the epidermis. It now appears that an integrated proteolytic network operates within the epidermis, comprising more than 30 enzymes that carry out a growing list of essential functions. Equally, defective regulation or execution of protease-mediated processes is emerging as a key contributor to diverse human skin pathologies, and in recent years the number of diseases attributable to aberrant proteolytic activity has more than doubled. Here, we survey the different roles of proteases in epidermal homeostasis (from processing enzymes to signalling molecules) and explore the spectrum of rare and common human skin disorders where proteolytic pathways are dysregulated.

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25 citations in Scopus
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20 citations in Web of Science®

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ID Code: 70817
Item Type: Journal Article
Refereed: Yes
Keywords: allergy; differentiation; epidermis; homeostasis; inflammation; keratinocyte
DOI: 10.1016/j.molmed.2013.11.005
ISSN: 1471-4914
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Elsevier Ltd.
Deposited On: 01 May 2014 01:47
Last Modified: 13 May 2014 22:28

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