Proteases and proteomics : cutting to the core of human skin pathologies

de Veer, Simon J., Furio, Laetitia, Harris, Jonathan, & Hovnanian, Alain (2014) Proteases and proteomics : cutting to the core of human skin pathologies. Proteomics - Clinical Applications, 8(5-6), pp. 389-402.

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Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks escape of water and electrolytes from within. This structure exists in a perpetual state of regeneration where the production of new cellular subunits at the base of the epidermis is offset by the release of terminally differentiated corneocytes from the surface. It is becoming increasingly clear that proteases hold vital roles in assembling and maintaining the epidermal barrier. More than 30 proteases are expressed by keratinocytes or infiltrating immune cells and the activity of each must be maintained within narrow limits and confined to the correct time and place. Accordingly, over- or under-exertion of proteolytic activity is a common factor in a multitude of skin disorders that range in severity from relatively mild to life-threatening. This review explores the current state of knowledge on the involvement of proteases in skin diseases and the latest findings from proteomic and transcriptomic studies focused on uncovering novel (patho)physiological roles for these enzymes.

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9 citations in Scopus
9 citations in Web of Science®
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ID Code: 70834
Item Type: Journal Article
Refereed: Yes
Additional Information: Article first published online: 13 APR 2014
Keywords: Epidermis; Inflammation; Keratinocyte; Permeability barrier; Therapeutic target
DOI: 10.1002/prca.201300081
ISSN: 1862-8354
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Deposited On: 01 May 2014 02:01
Last Modified: 21 Jun 2017 03:01

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