Design, characterisation and in vivo testing of a new, adjustable stiffness, external fixator for the rat femur

Glatt, V., Evans, C.H., & Matthys, R. (2012) Design, characterisation and in vivo testing of a new, adjustable stiffness, external fixator for the rat femur. European Cells and Materials, 23, pp. 289-299.

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Abstract

Very little is known about the infl uence of the mechanical environment on the healing of large segmental defects. This partly reflects the lack of standardised, well characterised technologies to enable such studies. Here we report the design, construction and characterisation of a novel external fixator for use in conjunction with rat femoral defects. This device not only imposes a predetermined axial stiffness on the lesion, but also enables the stiffness to be changed during the healing process. The main frame of the fi xator consists of polyethylethylketone with titanium alloy mounting pins. The stiffness of the fi xator is determined by interchangeable connection elements of different thicknesses. Fixators were shown to stabilise 5 mm femoral defects in rats in vivo for at least 8 weeks during unrestricted cage activity. No distortion or infections, including pin infections, were noted. The healing process was simulated in vitro by inserting into a 5 mm femoral defect, materials whose Young’s moduli approximated those of the different tissues present in regenerating bone. These studies confirmed that, although the external fixator is the major determinant of axial stiffness during the early phase of healing, the regenerate within the lesion subsequently dominates this property. There is much clinical interest in altering the mechanics of the defect to enhance bone healing. Our data suggest that, if alteration of the mechanical environment is to be used to modulate the healing of large segmental defects, this needs to be performed before the tissue properties become dominant.

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8 citations in Web of Science®

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ID Code: 70840
Item Type: Journal Article
Refereed: Yes
Keywords: External fixator, bone healing, small animal model, mechanical stiffness, mechanobiology, dynamisation
ISSN: 1473-2262
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 01 May 2014 01:09
Last Modified: 01 May 2014 22:54

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