A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

Pearsall, R. Scott, Canalis, Ernesto, Cornwall-Brady, Milton, Underwood, Kathryn W., Haigis, Brendan, Ucran, Jeffrey, Kumar, Ravindra, Pobre, Eileen, Grinberg, Asya, Werner, Eric D., Glatt, Vaida, Stadmeyer, Lisa, Smith, Deanna, Seehra, Jasbir, & Bouxsein, Mary L. (2008) A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity. National Academy of Sciences. Proceedings, 105(19), pp. 7082-7087.

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Diseases that affect the regulation of bone turnover can lead to skeletal fragility and increased fracture risk. Members of the TGF-superfamily have been shown to be involved in the regulation of bone mass. Activin A, a TGF-� signaling ligand, is present at high levels in bone and may play a role in the regulation of bone metabolism. Here we demonstrate that pharmacological blockade of ligand signaling through the high affinity receptor for activin, type II activin receptor (ActRIIA), by administration of the soluble extracellular domain of ActRIIA fused to a murine IgG2a-Fc, increases bone formation, bone mass, and bone strength in normal mice and in ovariectomized mice with established bone loss. These observations support the development of this pharmacological strategy for the treatment of diseases with skeletal fragility.

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ID Code: 70893
Item Type: Journal Article
Refereed: Yes
Keywords: anabolic, osteoporosis, TGF-beta�, therapeutic
DOI: 10.1073/pnas.0711263105
ISSN: 1091-6490
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: © 2008 by The National Academy of Sciences of the USA
Deposited On: 01 May 2014 05:42
Last Modified: 09 Jun 2014 23:44

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