A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity
Pearsall, R. Scott, Canalis, Ernesto, Cornwall-Brady, Milton, Underwood, Kathryn W., Haigis, Brendan, Ucran, Jeffrey, Kumar, Ravindra, Pobre, Eileen, Grinberg, Asya, Werner, Eric D., Glatt, Vaida, Stadmeyer, Lisa, Smith, Deanna, Seehra, Jasbir, & Bouxsein, Mary L. (2008) A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity. National Academy of Sciences. Proceedings, 105(19), pp. 7082-7087.
Diseases that affect the regulation of bone turnover can lead to skeletal fragility and increased fracture risk. Members of the TGF-superfamily have been shown to be involved in the regulation of bone mass. Activin A, a TGF-� signaling ligand, is present at high levels in bone and may play a role in the regulation of bone metabolism. Here we demonstrate that pharmacological blockade of ligand signaling through the high affinity receptor for activin, type II activin receptor (ActRIIA), by administration of the soluble extracellular domain of ActRIIA fused to a murine IgG2a-Fc, increases bone formation, bone mass, and bone strength in normal mice and in ovariectomized mice with established bone loss. These observations support the development of this pharmacological strategy for the treatment of diseases with skeletal fragility.
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|Item Type:||Journal Article|
|Keywords:||anabolic, osteoporosis, TGF-beta�, therapeutic|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||© 2008 by The National Academy of Sciences of the USA|
|Deposited On:||01 May 2014 05:42|
|Last Modified:||09 Jun 2014 23:44|
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