Cancer : the to and fro of tumour spread
Van Denderen, Bryce J.W. & Thompson, Erik W. (2013) Cancer : the to and fro of tumour spread. Nature, 493(7433), pp. 487-488.
The spread of cells from the primary site of a solid tumour to distant sites remains the major cause of disease and death associated with these cancers. For tumour cells to spread, or metastasize, they must modify their 'anchored' state and detach from their neighbouring cells; migrate through tissues into the blood and lymph systems; survive in these circulation systems; and then leave the vessels at an appropriate site to form another tumour1. Many of these events are favoured by conversions between two cellular states — the epithelial and mesenchymal phenotypes. But the role of these transitions in cancer metastasis is controversial. Writing in Cancer Cell, Tsai et al.2 and Ocaña et al.3 help to clarify this issue...
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|Item Type:||Journal Article|
|Additional Information:||Cited By (since 1996):6
Export Date: 6 May 2014
PubMed ID: 23344357
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Deposited On:||07 May 2014 03:31|
|Last Modified:||07 May 2014 23:33|
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