Progress in epithelial-mesenchymal transition research

Newgreen, D.F. & Thompson, E.W. (2013) Progress in epithelial-mesenchymal transition research. Cells, Tissues, Organs, 197(6), pp. 421-423.

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Abstract

The field of research of epithelial-mesenchymal transitions, EMT, and its reverse, mesenchymal-epithelial transitions, MET, has expanded very rapidly indeed from its beginnings, heralded by Professor Betty Hay in the 1970s and 1980s. This expansion has involved the realisation that the EMT was not just an interesting phenomenon of early developmental morphogenetic cell behaviour, but bore remarkable resemblance to clinically crucial pathological events in cancer invasion. Not surprisingly, this discipline soon became numerically dominant in the EMT publication field. Simultaneously, the EMT concept has been extended to normal physiological wound healing. Exploration revealed that these resemblances were more than skin deep: the same sets of growth factors, receptors, transcription factors, epigenetic marks and signalling pathways turned up repeatedly in EMTs and METs in a variety of contexts, both pathological and normal. This molecular genetic research in turn uncovered similarities of the EMT signature to that of fibrosis, a set of diseases which is of enormous clinical importance, rivalling that of cancer. Most recently, and more surprisingly, the EMT signature has shown considerable similarity to that found in stem cell and cancer stem cell biology.

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ID Code: 71131
Item Type: Journal Article
Refereed: Yes
Additional Information: Export Date: 6 May 2014
Source: Scopus
PubMed ID: 23774311
DOI: 10.1159/000351732
ISSN: 1422-6405
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 07 May 2014 03:14
Last Modified: 05 Jun 2014 22:10

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