Exploration of mechanisms underlying the strain-rate-dependent mechanical property of single chondrocytes

Nguyen, Trung Dung & Gu, YuanTong (2014) Exploration of mechanisms underlying the strain-rate-dependent mechanical property of single chondrocytes. Applied Physics Letters, 104, p. 183701.

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Abstract

Based on the characterization by Atomic Force Microscopy (AFM), we report that the mechanical property of single chondrocytes has dependency on the strain-rates. By comparing the mechanical deformation responses and the Young’s moduli of living and fixed chondrocytes at four different strain-rates, we explore the deformation mechanisms underlying this dependency property. We found that the strain-rate-dependent mechanical property of living cells is governed by both of the cellular cytoskeleton (CSK) and the intracellular fluid when the fixed chondrocytes is mainly governed by their intracellular fluid which is called the consolidation-dependent deformation behavior. Finally, we report that the porohyperelastic (PHE) constitutive material model which can capture the consolidation-dependent behavior of both living and fixed chondrocytes is a potential candidature to study living cell biomechanics.

Impact and interest:

10 citations in Scopus
7 citations in Web of Science®
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ID Code: 71284
Item Type: Journal Article
Refereed: Yes
DOI: 10.1063/1.4876056
ISSN: 1077-3118
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Copyright 2014 AIP Publishing LLC.
Deposited On: 11 May 2014 22:42
Last Modified: 13 May 2014 15:45

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