Indexes of insulin resistance and secretion in obese children and adolescents : a validation study
Conwell, L.S., Trost, S.G., Brown, W.J., & Batch, J.A. (2004) Indexes of insulin resistance and secretion in obese children and adolescents : a validation study. Diabetes Care, 27(2), pp. 314-319.
To assess the concurrent validity of fasting indexes of insulin sensitivity and secretion in - obese prepubertal (Tanner stage 1) children and pubertal (Tanner stages 2-5) glucose tolerance test (FSIVGTT) as a criterion measure.
RESEARCH DESIGN AND METHODS
Eighteen obese children and adolescents (11 girls and 7 boys, mean age 12.2 +/- 2.4 years, mean BMI 35.4 +/- 6.2 kg/m(2), mean BMI-SDS 3.5 +/- 0.5, 7 prepubertal and I I pubertal) participated in the study. All participants underwent an insulin-modified FSIVGTT on two occasions, and 15 repeated this test a third time (mean 12.9 and 12.0 weeks apart). S-i measured by the FSIVGTT was compared with homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), fasting glucose-to-insulin ratio (FGIR), and fasting insulin (estimates of insulin sensitivity derived from fasting samples). The acute insulin response (AIR) measured by the FSIVGTT was compared with HOMA of percent beta-cell function (HOMA-beta%), FGIR, and fasting insulin (estimates of insulin secretion derived from fasting samples).
There was a significant negative correlation between HOMA-IR and S-i (r = -0.89, r = -0.90, and r = -0.81, P < 0.01) and a significant positive correlation between QUICKI and S-i (r = 0.89, r = 0.90, and r = 0.81, P < 0.01) at each time point. There was a significant positive correlation between FGIR and S-i (r = 0.91, r = 0.91, and r = 0.82, P < 0.01) and a significant negative correlation between fasting insulin and S-i (r = -90, r = -0.90, and r = -0.88, P < 0.01). HOMA-beta% was not as strongly correlated with AIR (r = 0.60, r = 0.54, and r = 0.61, P < 0.05).
HOMA-IR, QUICKI, FGIR, and fasting insulin correlate strongly with S-i assessed by the FSIVGTT in obese children and adolescents. Correlations between HOMA-β% FGIR and fasting insulin, and AIR were not as strong. Indexes derived from fasting samples are a valid tool for assessing insulin sensitivity in prepubertal and pubertal obese children.
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|Item Type:||Journal Article|
|Additional Information:||Articles free to read on journal website after 6 months ISI Document Delivery No.: 770PU Times Cited: 163 Cited Reference Count: 43 Conwell, LS Trost, SG Brown, WJ Batch, JA Amer diabetes assoc Alexandria|
|Keywords:||homeostasis model assessment, beta-cell function, polycystic-ovary-syndrome, sensitivity check index, minimal-model, glucose-tolerance, african-american, prepubertal children, pubertal, changes, fasting glucose|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Deposited On:||13 May 2014 04:07|
|Last Modified:||03 Feb 2015 05:28|
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