Direct evidence for base-mediated decomposition of alkyl hydroperoxides (ROOH) in the gas phase
Blanksby, Stephen J., Ellison, G. B., Bierbaum, V. M., & Kato, S. (2002) Direct evidence for base-mediated decomposition of alkyl hydroperoxides (ROOH) in the gas phase. Journal of the American Chemical Society, 124(13), pp. 3196-3197.
Alkyl hydroperoxides (ROOH) are attributed a key role in the biochemical oxidation of lipids during oxidative stress.1 In this chemistry ROOH compounds, where the R groups are unsaturated fatty acids, are viewed as transient ntermediates which are readily degraded, due to the lability of the RO-OH bond, to yield potentially genotoxic aldehydes and ketones.2 Generally, the decomposition of alkyl hydroperoxides is thought to be mediated by radical abstraction or electron transfer processes usually involving enzymes, transition metals, or recently, Vitamin C.3 In this paper we present the first unambiguous experimental and computational evidence for base-mediated heterolytic decomposition of simple alkyl hydroperoxides by the mechanism outlined in Scheme 1.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|ISSN:||1520-5216 (online) 0002-7863 (print)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright © 2002 American Chemical Society|
|Deposited On:||21 May 2014 01:50|
|Last Modified:||21 May 2014 01:50|
Repository Staff Only: item control page