Molecular sliding filament model for muscular contraction based on multiscale investigation

Li, Tong, Gu, YuanTong, & Oloyede, Adekunle (2014) Molecular sliding filament model for muscular contraction based on multiscale investigation. Science of Advanced Materials, 6(7), pp. 1346-1350.

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Abstract

A multiscale approach that bridges the biophysics of the actin molecules at nanoscale and the biomechanics of actin filament at microscale level is developed and used to evaluate the mechanical performances of actin filament bundles. In order to investigate the contractile properties of skeletal muscle which is induced by the protein motor of myosin, a molecular model is proposed in the prediction of the dynamic behaviors of skeletal muscle based on classic sliding filament model. Randomly distributed myosin motors are applied on a 2.2 μm long sarcomere, whose principal components include actin and myosin filaments. It can be found that, the more myosin motors on the sarcomere, the faster the sarcomere contracts. The result demonstrates that the sarcomere shortening speed cannot increase infinitely by the modulation of myosin, thus providing insight into the self-protective properties of skeletal muscles. This molecular filament sliding model provides a theoretical way to evaluate the properties of skeletal muscles, and contributes to the understandings of the molecular mechanisms in the physiological phenomenon of muscular contraction.

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ID Code: 71679
Item Type: Journal Article
Refereed: Yes
Keywords: ACTIN, MULTISCALE, MUSCULAR CONTRACTION, MYOSIN, SARCOMERE
DOI: 10.1166/sam.2014.1822
ISSN: 1947-2935
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Copyright 2014 American Scientific Publishers
Deposited On: 16 May 2014 01:27
Last Modified: 02 Aug 2015 09:53

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