PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma

Chaffer, Christine L., Thomas, David M., Thompson, Erik W., & Williams, Elizabeth D. (2006) PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. BMC Cancer, 6(53).

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Although PPARγ antagonists have shown considerable pre-clinical efficacy, recent studies suggest PPARγ ligands induce PPARγ-independent effects. There is a need to better define such effects to permit rational utilization of these agents.


We have studied the effects of a range of endogenous and synthetic PPARγ ligands on proliferation, growth arrest (FACS analysis) and apoptosis (caspase-3/7 activation and DNA fragmentation) in multiple prostate carcinoma cell lines (DU145, PC-3 and LNCaP) and in a series of cell lines modelling metastatic transitional cell carcinoma of the bladder (TSU-Pr1, TSU-Pr1-B1 and TSU-Pr1-B2).


15-deoxy-prostaglandin J2 (15dPGJ2), troglitazone (TGZ) and to a lesser extent ciglitazone exhibited inhibitory effects on cell number; the selective PPARγ antagonist GW9662 did not reverse these effects. Rosiglitazone and pioglitazone had no effect on proliferation. In addition, TGZ induced G0/G1 growth arrest whilst 15dPGJ2 induced apoptosis.


Troglitazone and 15dPGJ2 inhibit growth of prostate and bladder carcinoma cell lines through different mechanisms and the effects of both agents are PPARγ-independent.

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ID Code: 71719
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):64
Export Date: 6 May 2014
Source: Scopus
Art. No.: 53
PubMed ID: 16519808
Additional URLs:
DOI: 10.1186/1471-2407-6-53
ISSN: 1471-2407
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2006 Chaffer et al; licensee BioMed Central Ltd.
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 16 May 2014 02:05
Last Modified: 21 May 2014 03:51

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