Epithelial to mesenchymal transition and breast cancer
Tomaskovic-Crook, Eva, Thompson, Erik W., & Thiery, Jean Paul (2009) Epithelial to mesenchymal transition and breast cancer. Breast Cancer Research, 11(213).
Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.
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|Item Type:||Journal Article|
|Additional Information:||Cited By (since 1996):83
Export Date: 6 May 2014
Art. No.: 213
PubMed ID: 19909494
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Copyright Owner:||Copyright 2009 BioMed Central Ltd|
|Deposited On:||16 May 2014 03:31|
|Last Modified:||21 May 2014 04:15|
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