Epithelial to mesenchymal transition and breast cancer

Tomaskovic-Crook, Eva, Thompson, Erik W., & Thiery, Jean Paul (2009) Epithelial to mesenchymal transition and breast cancer. Breast Cancer Research, 11(213).

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Abstract

Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.

Impact and interest:

155 citations in Scopus
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138 citations in Web of Science®

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24 since deposited on 16 May 2014
2 in the past twelve months

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ID Code: 71737
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):83
Export Date: 6 May 2014
Source: Scopus
Art. No.: 213
PubMed ID: 19909494
Additional URLs:
DOI: 10.1186/bcr2416
ISSN: 1465-542X
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2009 BioMed Central Ltd
Deposited On: 16 May 2014 03:31
Last Modified: 21 May 2014 04:15

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