Roles of the matrix metalloproteinases in mammary gland development and cancer

Benaud, C., Dickson, R.B., & Thompson, E.W. (1998) Roles of the matrix metalloproteinases in mammary gland development and cancer. Breast Cancer Research and Treatment, 50(2), pp. 97-116.

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Abstract

Tissue remodeling is a key process involved in normal development, wound healing, bone remodeling, and embryonic implantation, as well as pathological conditions such as tumor invasion and metastasis, and angiogenesis. The degradation of the extracellular matrix that is associated with those processes is mediated by a number of families of extracellular proteinases. These families include the serine proteinases, such as the plasminogen-urokinase plasminogen activator system and leukocyte elastases, the cysteine proteinases, like cathepsin D and L, and the zinc-dependent matrix metalloproteinases (MMPs). Accumulating evidence has highlighted the central role of MMP-driven extracellular matrix remodeling in mammary gland development and breast cancer.

Impact and interest:

103 citations in Scopus
97 citations in Web of Science®
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ID Code: 71739
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):96
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 9822215
Additional URLs:
Keywords: Breast cancer, Breast development, MMP
DOI: 10.1023/A:1006061115909
ISSN: 1573-7217
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 16 May 2014 04:11
Last Modified: 21 Jun 2017 10:01

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