Hormone resistance, invasiveness, and metastatic potential in breast cancer

Clarke, Robert, Thompson, Erik W., Leonessa, Fabio, Lippman, Jeremy, McGarvey, Michael, Frandsen, Thomas L., & Brunner, Nils (1993) Hormone resistance, invasiveness, and metastatic potential in breast cancer. Breast Cancer Research and Treatment, 24(3), pp. 227-239.

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Critical phenotypic changes that occur during the progression of breast cancer include the loss of hormone-dependence, acquired resistance to systemic therapies, and increased metastatic potential. We have isolated a series of MCF-7 human breast cancer variants which exhibit hormone-independent growth, antiestrogen resistance, and increased metastatic potential. Analysis of the phenotypes of these variants strongly suggests that changes in the expression of specific genes may be critical to the generation of phenotypic diversity in the process of malignant progression in breast cancer. Epigenetic changes may contribute significantly to the generation of these phenotypic changes observed during breast cancer progression. Many of the characteristics of the progressed phenotypes appear to have arisen in response to appropriate selective pressures (growth in ovariectomized nude mice; growth in the presence of antiestrogens). These observations are consistent with the concept of clonal selection and expansion in the process of malignant progression.

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64 citations in Scopus
69 citations in Web of Science®
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ID Code: 71742
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):52
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 8435478
Additional URLs:
DOI: 10.1007/BF01833263
ISSN: 1573-7217
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 16 May 2014 03:35
Last Modified: 21 Jun 2017 10:01

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