Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells

Spiegel, S., Olivera, A., Zhang, H., Thompson, E.W., Su, Y., & Berger, A. (1994) Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells. Breast Cancer Research and Treatment, 31(2-3), pp. 337-348.

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Abstract

This review will focus on the role of sphingosine and its phosphorylated derivative sphingosine-1-phosphate (SPP) in cell growth regulation and signal transduction. We will show that many of the effects attributed to sphingosine in quiescent Swiss 3T3 fibroblasts are mediated via its conversion to SPP. We propose that SPP has appropriate properties to function as an intracellular second messenger based on the following: it elicits diverse cellular responses; it is rapidly produced from sphingosine by a specific kinase and rapidly degraded by a specific lyase; its concentration is low in quiescent cells but increases rapidly and transiently in response to the growth factors, fetal calf serum (FCS) and platelet derived growth factor (PDGF); it releases Ca2+ from internal sources in an InsP3-independent manner; and finally, it may link sphingolipid signaling pathways to cellular ras-mediated signaling pathways by elevating phosphatidic acid levels. The effects of this novel second messenger on growth, differentiation and invasion of human breast cancer cells will be discussed. © 1994 Kluwer Academic Publishers.

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38 citations in Scopus
34 citations in Web of Science®
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ID Code: 71746
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):36
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 7881110
Additional URLs:
Keywords: human breast cancer cells, invasiveness, PDGF, sphingolipid metabolites, sphingosine-1-phosphate
DOI: 10.1007/BF00666166
ISSN: 1573-7217
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 16 May 2014 04:24
Last Modified: 21 Jun 2017 10:01

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