Preparation and in vitro evaluation of a polymer based controlled release dry powder inhaler formulation for pulmonary delivery

Muhsin, Mohammad Didare Alam (2014) Preparation and in vitro evaluation of a polymer based controlled release dry powder inhaler formulation for pulmonary delivery. PhD thesis, Queensland University of Technology.


This thesis described the synthesis of an L-leucine conjugate of the biodegradable polymer, chitosan and its potential application for the development of controlled release nanoparticulate dry powder inhaler (DPI) formulations. The study demonstrated that the physicochemical properties of conjugated chitosan nanoparticles had favourable effects on the dispersibility and controlled release profile of a model drug. The toxicity profile of the nanoparticulate formulation revealed promising outcome for its use in pulmonary delivery. The chitosan conjugate produced in this project would be useful for the application of polymer nanoparticulate systems for efficient lung delivery of drugs.

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ID Code: 71806
Item Type: QUT Thesis (PhD)
Supervisor: Islam, Nazrul, George, Graeme, Beagley, Kenneth, & Ferro, Vito
Keywords: Chitosan, L-leucine, Conjugation, Nanoparticle, Dry powder inhaler (DPI), Pulmonary delivery, Aerosolization/ Dispersion, Controlled release, Diltiazem hydrochloride, BEAS-2B
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 03 Jun 2014 01:43
Last Modified: 24 Apr 2016 00:02

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