Bimolecular interaction of Insulin-Like Growth Factor (IGF) binding protein-2 with αvβ3 negatively modulates IGF-I-Mediated migration and tumor growth
Pereira, J.J., Meyer, T., Docherty, S.E., Reid, H.H., Marshall, J., Thompson, E.W., Rossjohn, J., & Price, J.T. (2004) Bimolecular interaction of Insulin-Like Growth Factor (IGF) binding protein-2 with αvβ3 negatively modulates IGF-I-Mediated migration and tumor growth. Cancer Research, 64(3), pp. 977-984.
Both the integrin and insulin-like growth factor binding protein (IGFBP) families independently play important roles in modulating tumor cell growth and progression. We present evidence for a specific cell surface localization and a bimolecular interaction between the αvβ3 integrin and IGFBP-2. The interaction, which could be specifically perturbed using vitronectin and αvβ3 blocking antibodies, was shown to modulate IGF-mediated cellular migration responses. Moreover, this interaction was observed in vivo and correlated with reduced tumor size of the human breast cancer cells, MCF-7β3, which overexpressed the αvβ3 integrin. Collectively, these results indicate that αvβ3 and IGFBP-2 act cooperatively in a negative regulatory manner to reduce tumor growth and the migratory potential of breast cancer cells.
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|Item Type:||Journal Article|
|Additional Information:||Articles free to read on journal website after 12 months Cited By (since 1996):56 Export Date: 6 May 2014 Source: Scopus PubMed ID: 14871828|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Deposited On:||20 May 2014 03:24|
|Last Modified:||28 Jan 2015 01:57|
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