Carcinoma invasion and metastasis : a role for epithelial-mesenchymal transition?

Thompson, Erik W. & Newgreen, Donald F. (2005) Carcinoma invasion and metastasis : a role for epithelial-mesenchymal transition? Cancer Research, 65(14), pp. 5991-5995.

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Carcinogenesis involves the accretion of unprogrammed genetic and epigenetic changes, which lead to dysregulation of the normal control of cell number. But a key clinical turning point in carcinoma progression is the establishment by emigrant cells of secondary growth sites (i.e., metastasis). The metastatic “cascade” comprises numerous steps, including escape from the primary tumor site, penetration of local stroma, entry of local vascular or lymphatic vessels (intravasation), aggregation with platelets, interaction with and adhesion to distant endothelia, extravasation, recolonization, and expansion ( 1), all the time avoiding effective immune clearance and being able to survive in these multiple contexts...

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378 citations in Web of Science®

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ID Code: 71834
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 12 months
Cited By (since 1996):303
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 16024595
Additional URLs:
DOI: 10.1158/0008-5472.CAN-05-0616
ISSN: 0008-5472
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 20 May 2014 02:07
Last Modified: 28 Jan 2015 01:50

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