Epithelial mesenchymal transition traits in human breast cancer cell lines

Blick, T., Widodo, E., Hugo, Honor J., Waltham, M., Lenburg, M.E., Neve, R.M., & Thompson, E.W. (2008) Epithelial mesenchymal transition traits in human breast cancer cell lines. Clinical and Experimental Metastasis, 25(6), pp. 629-642.

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Epithelial mesenchymal transition (EMT) has long been associated with breast cancer cell invasiveness and evidence of EMT processes in clinical samples is growing rapidly. Genome-wide transcriptional profiling of increasingly larger numbers of human breast cancer (HBC) cell lines have confirmed the existence of a subgroup of cell lines (termed Basal B/Mesenchymal) with enhanced invasive properties and a predominantly mesenchymal gene expression signature, distinct from subgroups with predominantly luminal (termed Luminal) or mixed basal/luminal (termed Basal A) features (Neve et al Cancer Cell 2006). Studies providing molecular and cellular analyses of EMT features in these cell lines are summarised, and the expression levels of EMT-associated factors in these cell lines are analysed. Recent clinical studies supporting the presence of EMT-like changes in vivo are summarised. Human breast cancer cell lines with mesenchymal properties continue to hold out the promise of directing us towards key mechanisms at play in the metastatic dissemination of breast cancer.

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186 citations in Scopus
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169 citations in Web of Science®

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ID Code: 71905
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):132
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 18461285
Additional URLs:
Keywords: Basal, Breast cancer, Breast cancer stem cells, EMT, Luminal, Mesenchymal
DOI: 10.1007/s10585-008-9170-6
ISSN: 1573-7276
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 22 May 2014 01:15
Last Modified: 29 Aug 2016 07:16

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