Identification of double bond position in lipids : From GC to OzID

Mitchell, T. W., Pham, H., Thomas, M. C., & Blanksby, Stephen J. (2009) Identification of double bond position in lipids : From GC to OzID. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 877(26), pp. 2722-2735.

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Recent developments in mass spectrometry and chromatography provide new possibilities for the identification and in some instances quantification of a wide range of lipids in complex matrices. These advances in analytical technologies have provided a tantalizing glimpse of the true structural diversity of lipids in nature and have reinvigorated interest in the role of lipids in biology. While technological advances have been impressive, difficulties in the ready identification of sites of unsaturation (i.e., double bond position) within these molecules presents a significant impediment to understanding lipid biochemistry. This is of particular importance given the growing body of literature suggesting that the presence of naturally occurring lipid double bond isomers can have a significant influence, both positive and negative, on the development of pathologies such as cancer, cardiovascular disease and type 2 diabetes. This article provides a critical review of the Current suite of analytical approaches to the challenge of identification of the position of carbon-carbon double bonds in intact lipids. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.

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ID Code: 71938
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: ESI-MS, Lipidomics, Lipids, Double bond position, tandem mass-spectrometry, unsaturated fatty-acids, performance, liquid-chromatography, collisionally activated dissociation, dimethyl, disulfide derivatives, stage quadrupole instrument, fast-atom-bombardment, rat skeletal-muscle, electrospray-ionization, methyl-esters
DOI: 10.1016/j.jchromb.2009.01.017
ISSN: 1873-376X (online) 1570-0232 (print)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Crown Copyright © 2009 Published by Elsevier B.V. All rights reserved.
Deposited On: 21 May 2014 22:48
Last Modified: 30 May 2014 06:12

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