Effects of short-duration and long-duration exercise on lipoprotein(a)

Durstine, J.L., Davis, P.G., Ferguson, M.A., Alderson, N.L., & Trost, S.G. (2001) Effects of short-duration and long-duration exercise on lipoprotein(a). Medicine and Science in Sports and Exercise, 33(9), pp. 1511-1516.

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Abstract

Purpose

Most studies that use either a single exercise session, exercise training, or a cross-sectional design have failed to find a relationship between exercise and plasma lipoprotein(a) [Lp(a)] concentrations. However, a few studies investigating the effects of longer and/or more strenuous exercise have shown elevated Lp(a) concentrations, possibly as an acute-phase reactant to muscle damage. Based on the assumption that greater muscle damage would occur with exercise of longer duration, the purpose of the present study was to determine whether exercise of longer duration would increase Lp(a) concentration and creatine kinase. (CK) activity more than exercise of shorter duration.

Methods

Ten endurance-trained men (mean +/- SD: age, 27 +/- 6 yr; maximal oxygen consumption [(V)over dotO(2max)], 57 +/- 7 mL(.)kg(-1) min(-1)) completed two separate exercise sessions at 70% (V)over dotO(2max). One session required 900 kcal of energy expenditure (60 +/- 6 min), and the other required 1500 kcal (112 +/- 12 min). Fasted blood samples were taken immediately before (0-pre), immediately after (0-post), 1 d after (1-post), and 2 d after (2-post) each exercise session.

Results

CK activity increased after both exercise sessions (mean +/- SE; 800 kcal: 0-pre 55 +/- 11, 1-post 168 +/- 64 U(.)L(-1.)min(-1); 1500 kcal: 0-pre 51 +/- 5, 1-post 187 +/- 30, 2-post 123 +/- 19 U(.)L(-1.)min(-1); P < 0.05). However, median Lp(a) concentrations were not altered by either exercise session (800 kcal: 0-pre 5.0 mg(.)dL(-1), 0-post 3.2 mg(.)dL(-1), 1-post 4.0 mg(.)dL(-1), 2-post 3.4 mg(.)dL(-1); 1500 kcal: 0-pre 5.8 mg(.)dL(-1), 0-post 4.3 mg(.)dL(-1), 1-post 3.2 mg(.)dL(-1), 2-post 5.3 mg(.)dL(-1)). In addition, no relationship existed between exercise-induced changes in CK activity and Lp(a) concentration (800 kcal: r = -0.26; 1500 kcal: r = -0.02).

Conclusion

These results suggest that plasma Lp(a) concentration will not increase in response to minor exercise-induced muscle damage in endurance-trained runners.

Impact and interest:

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11 citations in Web of Science®

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ID Code: 71957
Item Type: Journal Article
Refereed: Yes
Additional Information: ISI Document Delivery No.: 470CY
Times Cited: 11
Cited Reference Count: 36
Durstine, JL Davis, PG Ferguson, MA Alderson, NL Trost, SG
Lippincott williams & wilkins
Philadelphia;<Go to ISI>://WOS:000170853900014
Keywords: creatine kinase, muscle damage, elevated serum lipoprotein(a), physical-activity, plasma lipoprotein(a), eccentric exercise, sedentary controls, endothelial-cells, sample, storage, lp(a) levels, lipids, fitness
DOI: 10.1097/00005768-200109000-00014
ISSN: 0195-9131
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 22 May 2014 04:27
Last Modified: 22 May 2014 04:27

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