Mesenchymal to epithelial transition in development and disease

Chaffer, C.L., Thompson, E.W., & Williams, E.D. (2007) Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs, 185(1-3), pp. 7-19.

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Abstract

Cellular plasticity is fundamental to embryonic development. The importance of cellular transitions in development is first apparent during gastrulation when the process of epithelial to mesenchymal transition transforms polarized epithelial cells into migratory mesenchymal cells that constitute the embryonic and extraembryonic mesoderm. It is now widely accepted that this developmental pathway is exploited in various disease states, including cancer progression. The loss of epithelial characteristics and the acquisition of a mesenchymal-like migratory phenotype are crucial to the development of invasive carcinoma and metastasis. However, given the morphological similarities between primary tumour and metastatic lesions, it is likely that tumour cells re-activate certain epithelial properties through a mesenchymal to epithelial transition (MET) at the secondary site, although this is yet to be proven. MET is also an essential developmental process and has been extensively studied in kidney organogenesis and somitogenesis. In this review we describe the process of MET, highlight important mediators, and discuss their implication in the context of cancer progression.

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155 citations in Scopus
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136 citations in Web of Science®

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ID Code: 72051
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):106
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 17587803
Additional URLs:
Keywords: Bladder, Cancer, Epithelial to mesenchymal transition, Mesenchymal to epithelial transition, Metastasis
DOI: 10.1159/000101298
ISSN: 1422-6405
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 23 May 2014 01:03
Last Modified: 17 Jun 2014 00:57

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