Epithelial-mesenchymal transitions - new insights into signaling, development and pathogenesis

Thompson, E.W., Savagner, P., Dedhar, S., & Kalluri, R. (2007) Epithelial-mesenchymal transitions - new insights into signaling, development and pathogenesis. Cells Tissues Organs, 185(1-3), pp. 5-6.

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This 2nd special edition of Cells Tissues Organs on epithelial-mesenchymal transitions (EMT) stems from the 2nd International Conference on EMT, which was convened by Shoukat Dedhar and Raghu Kalluri on October 1–3, 2005, in Vancouver, B.C., Canada. EMT – the transformation of epithelial cells which are usually arranged in a coherent layer and sessile, into more individualistic and motile cells, mesenchymal cells – is well recognized as an important primary mechanism in embryogenesis for remodeling tissues, as is the reverse transition. This has obvious implications in numerous pathophysiologies, and in particular EMT has emerged as an important feature of fibrosis in a growing number of organ types. It is now clear that about a third of the fibroblasts in the setting of organ fibrosis are likely derived from the epithelium. Cancer EMT remains topical, and although EMT has been reported in many cancer studies, this meeting was held against a backdrop of controversy in the cancer community as to the prevalence of EMT in clinical scenarios [Tarin et al.: Cancer Res 2005;65:5996–6000; Thompson et al.: Cancer Res 2005;65:5991–5995]...

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ID Code: 72056
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):1
Export Date: 6 May 2014
Source: Scopus
Additional URLs:
DOI: 10.1159/000104413
ISSN: 1422-6405
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 23 May 2014 00:29
Last Modified: 17 Jun 2014 03:18

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