An acute growth factor treatment that preserves function after spinal cord contusion injury

Chehrehasa, Fatemeh, Cobcroft, Mitchell, Young, Yun Wai, Mackay-Sim, Alan, & Goss, Ben (2014) An acute growth factor treatment that preserves function after spinal cord contusion injury. Journal of Neurotrauma, 31(21), pp. 1807-1813.

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Abstract

Inflammation of the spinal cord after traumatic spinal cord injury leads to destruction of healthy tissue. This “secondary degeneration” is more damaging than the initial physical damage and is the major contributor to permanent loss of functions. In our previous study we showed that combined delivery of two growth factors, vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), significantly reduced secondary degeneration after hemi-section injury of the spinal cord in the rat. Growth factor treatment reduced the size of the lesion cavity at 30d compared to control animals and further reduced the cavity at 90d in treated animals while in control animals the lesion cavity continued to increase in size. Growth factor treatment also reduced astrogliosis and reduced macroglia/macrophage activation around the injury site. Treatment with individual growth factors alone had similar effects to control treatments. The present study investigated whether growth factor treatment would improve locomotor behaviour after spinal contusion injury, a more relevant preclinical model of spinal cord injury. The growth factors were delivered for the first 7d to the injury site via osmotic minipump. Locomotor behaviour was monitored at 1-28d after injury using the BBB score and at 30d using automated gait analysis. Treated animals had BBB scores of 18; Control animals scored 10. Treated animals had significantly reduced lesion cavities and reduced macroglia/macrophage activation around the injury site. We conclude that growth factor treatment preserved spinal cord tissues after contusion injury, thereby allowing functional recovery. This treatment has the potential to significantly reduce the severity of human spinal cord injuries.

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3 citations in Scopus
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2 citations in Web of Science®

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ID Code: 72098
Item Type: Journal Article
Refereed: Yes
Keywords: PDGF, VEGF, spinal cord injury, neural protection, neuroinflammation
DOI: 10.1089/neu.2013.3294
ISSN: 1557-9042
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurosciences not elsewhere classified (110999)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Medical Sciences
Copyright Owner: Copyright 2014 please consult author(s)
Deposited On: 25 May 2014 23:55
Last Modified: 24 May 2015 09:21

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