The epithelial to mesenchymal transition and metastatic progression in carcinoma

Gilles, Christine & Thompson, Erik W. (1996) The epithelial to mesenchymal transition and metastatic progression in carcinoma. Breast Journal, 2(1), pp. 83-96.

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Abstract

Many data have emerged in support of the concept that the promotion of a migratory phenotype in epithelial cells is the result of an EMT, which leads to the loss of differentiation and to the acquisition of several mesenchymal features. Such an event is likely to occur during the metastatic conversion enabling the metastatic cell to invade the connective tissue and disseminate. Even though it cannot be excluded that some cancer cells might constitutively express a metastatic phenotype, the EMT implicated in the tumor progression process would rather be transient, induced in certain cells of the primary tumor by different factors, and reversed when the cells settle down in secondary organs (as schematically represented in Figure 1). However, it is clear that the phenotype that would emerge from the EMT occurring during tumor progression would also be modulated by the genetic background of the cells and must be to some extent different than the ones observed in normal physiological processes, and must also vary from one tumor to another.

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ID Code: 72217
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):68
Export Date: 6 May 2014
Source: Scopus
Additional URLs:
DOI: 10.1111/j.1524-4741.1996.tb00076.x
ISSN: 1524-4741
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 29 May 2014 03:07
Last Modified: 29 May 2014 03:07

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